Those who are historically susceptible to hypoglycemia or those who are on diabetic medication should also consult with a medical professional. But all this aside, studies have reported that Tribulus Terrestris does not cause any major side effects and has a low risk of toxicity.
Now, while the recommended dosage is three times a day, morning, noon, and night, the effectiveness of Tribulus extract can be amplified if you time the dosage more specifically. Tribulus is very dose-specific, so you need to get the timing and amount correct before seeing the results you want.
The range that appears to work for most people is between 2. Because of how Tribulus interacts with the body and hormones, you want to take advantage of your normal rhythms. In the morning, take Tribulus right when you wake up because your blood glucose levels will be low. Always take Tribulus between meals. If you are looking to boost your athletic performance, boost your testosterone, and get a decent boost pre-workout, Tribulus is an excellent supplement to add to your nutrition and supplement regimen.
Tribulus Terrestris has been used for many years in ancient medicinal practices, and it has a long list of benefits paired with minimal side effects. Once you have found the ideal dosage level and cycle Tribulus in and out of your diet, you can begin to see a difference in your physique and performance.
Search Supps See more "Close Cart". Best Sellers See more "Close Cart". Shop by Goal See more "Close Cart". Shop by Type See more "Close Cart". Inside Gaspari See more "Close Cart". Tribulus is also marketed as a dietary supplement to improve sexual function and for body building due to the belief that it acts like testosterone in the body.
Laboratory and animal studies show that tribulus has medicinal effects against high blood pressure, diabetes, inflammation, infection, and cancer. The use of tribulus has been linked to adverse effects in both animals and humans. Due to its potential hormonal activities, prostate cancer patients should consult their physicians before using tribulus.
Tribulus is a perennial herb that grows in the subtropical regions of eastern and western Asia, southern Europe, and Africa. It is used in traditional Chinese medicine and in Ayurveda for chest pain, heart-related problems, dizziness, skin and eye disorders, to expel kidney stones, and as a diuretic and tonic. It is also marketed as a dietary supplement to enhance sexual function 25 and for body building 26 Preclinical studies indicate that tribulus has analgesic 1 , antihypertensive 2 3 , anti-inflammatory 4 28 , antiedematous 28 , antioxidant 5 6 , diuretic 7 , hypoglycemic 8 , antibacterial 9 , antifungal 9 10 , cardioprotective 29 , and anticancer properties 11 12 Saponins in tribulus were reported to inhibit platelet aggregation, in vitro 30 ; and to have antidepressive effects in a murine model In a diabetic neuropathic pain model, a standardized tribulus extract was found to be comparable to the drug Pregabalin, with significant increases in pain threshold responses Tribulus has also been shown to increase sperm production 13 , but its effects on modulating testosterone levels are mixed 14 In clinical studies, testosterone increases only occurred when tribulus was part of a combined supplement therapy, making it difficult to determine its contribution to this effect Data from randomized trials of tribulus for erectile dysfunction are mixed 33 49 50 A pilot study evaluating tribulus in men with partial androgen deficiency showed significant differences in testosterone levels and erectile function, but no significant differences in levels of luteinizing hormone In women, however, small studies indicate improvements in sexual dysfunction 35 36 ; and improvements in hypoactive sexual desire disorder in pre- and postmenopausal subjects 52 In addition, a formulation containing tribulus may be useful against bacterial vaginitis A tribulus extract used alone did not not improve androgenic status or physical performance among athletes 26 Saponins in tribulus have shown activity against breast 38 and prostate cancer cells 39 , and may protect against UVB-induced carcinogenesis In animal models, tribulus affected a significant reduction in tumor incidence, tumor burden, and cumulative number of papillomas 19 , and relieved cisplatin-induced renal toxicity Due to its purported hormonal activities, prostate cancer patients should consult with their physicians before using tribulus.
In vitro, cinnamic amides in tribulus fruits inhibit papain-like protease PLpro , an essential proteolytic enzyme which plays a critical role in virus-mediated RNA replication Di-p-coumaroylquinic acid derivatives in tribulus are associated with its antioxidant effects Aphrodisiac effects may be associated with the constituent protodioscin, which leads to an increase in some sex hormones The NO release effect may explain observed physiological responses to tribulus supplementation, independent of testosterone level In a study conducted in rats with ovarian cysts, tribulus extract showed a luteinizing effect related to gonadotropin-like activity Saponins exhibit cytotoxic and antihyperlipidemic effects In ischemic cells, polyphenol-mediated antioxidant activity with tribulus extract resulted in significant suppression of LDH release, ROS generation, and superoxide production In animal models, tribulus exerts a protective effect in diabetic rats by inhibiting oxidative stress 6 and lowering levels of glycosylated hemoglobin and cholesterols 8.
In diabetic neuropathic pain models, tribulus modulates oxidative stress and inflammatory cytokine release in a dose-dependent manner via increases in superoxide dismutase, catalase, glutathione peroxidase, and reduced glutathione and lipid peroxide levels In chronic mild stress models, the attenuation of serum corticotropin-releasing factor and cortisol levels by tribulus saponins suggest normalization of hypothalamic-pituitary-adrenal HPA axis hyperactivity Antihypertensive effects occur via arterial smooth muscle relaxation, NO release, and membrane hyperpolarization 3.
An aqueous extract also demonstrated angiotensin converting enzyme ACE -inhibition activity 2 that may help lower blood pressure. Phenolic acids such as chlorogenic acid, caffeic acid and 4-hydroxybenzoic acid may be responsible for reputed cardioprotective properties Tribulus extracts induce apoptosis and suppress cancer cell proliferation by activating caspase 3, dephosphorylating extracellular signal-related kinase ERK 1 and 2 15 , and by inhibiting nuclear factor NF-kappa B signaling Saponins from tribulus inhibit multiple-drug resistance of cancer cells In models of human prostate cancer, antitumor and antiangiogenic activities are attributed to cell-cycle arrest and apoptotic induction not involving the caspase pathway Saponins also act as a modulator of apoptosis: in normal human keratinocytes, saponins attenuate UVB-induced programmed cell death through inhibition of intrinsic apoptotic pathway, but enhance apoptotic response in squamous cell carcinomas In animal models, a hydroalcoholic extract of tribulus relieved cisplatin-induced renal toxicity, perhaps via diuretic effects that increase drug excretion, scavenging free radicals via increase in antioxidant enzymes, suppressing inflammatory agents, and acting on organic cation transporter 2 OCT2 proteins Tribulus extract was shown to limit formation of calcium oxalate and calcium hydrogen phosphate dihydrate crystals 21 22 , mineral compounds that can cause kidney stones.
Consumption of tribulus causes motor neuron adverse effects in animals by affecting the gamma-aminobutyric acid GABA receptors The steroidal saponin diosgenin is thought to be responsible for hepatotoxic effects associated with tribulus Transient GI problems including irritation of gastric mucosa and gastric reflux 36 , and nephrotoxicity 55 have been associated with consumption of tribulus.
Tribulus terrestris. Developing Your Personal Care Plan. Integrative Medicine at Home Membership Program. About Mind-Body Therapies. How It Works. Tribulus has not been shown to treat or prevent cancer in humans. Purported Uses. To treat cancer Tribulus showed anticancer activities in lab studies. It has not been tested in humans as a cancer treatment. To lower blood pressure Tribulus extract can relax blood vessels and may help to lower blood pressure.
To enhance sexual function Tribulus increases sperm production in animal models, but human studies of its effects on testosterone levels gave mixed results. The current evidence of its effects on erectile dysfunction are also not definitive.
However, small studies suggest that it may help female sexual dysfunction. Large-scale studies are needed to confirm this. To improve muscle strength and muscle mass A clinical study did not find any significant changes in muscle strength or mass with use of tribulus.
To treat infections Tribulus has antifungal activities in lab studies. Human data are lacking. To reduce pain Tribulus extract reduced inflammation in lab studies, but human studies have not been done. To treat kidney stones Tribulus can promote urination and stop calcium compounds that cause kidney stones from forming. However, these effects have not been studied in humans. Do Not Take If. You are taking diruetics: Tribulus may increase the effects of diuretic drugs.
Clinical relevance is not known. You are taking antihypertensive drugs: Tribulus may have an additional blood pressure lowering effect. You are taking antidiabetics: Tribulus may have additive blood sugar lowering effects. You are taking clopidogrel : Tribulus may increase the risk of blood clots. Stent thrombosis has been reported in patients following concurrent use of clopidogrel and an herbal formula containing tribulus. Side Effects. Gastrointestinal irritation Case reports of severe liver, kidney, and neurological toxicities and Priapism.
For Healthcare Professionals. Scientific Name. Clinical Summary. Mechanism of Action. Adverse Reactions. Neuro-, hepatic, and renal toxicity suggestive of acute tubular necrosis ATN : In a year-old man who consumed large quantities of tribulus extract for its antiurolithiatic properties.
Treats Infertility. Erectile Dysfunction , one of the prime reasons for male infertility, correlates with low levels of Didehydroepiandrosterone DHEA. Protodioscin, a constituent of tribulus is responsible for improving DHEA levels in the male system. It also improves sperm concentration and sperm motility. Several studies have consistently proven that regular intake of the extract increases ovulation in women who had abnormal ovulation patterns.
Tribulus terrestris supplements have been an operational cure for hypertension. Repeated research on rats shows that when aqueous extracts of the herb were administered to hypertensive rats, the blood pressure was indeed lowered. Additionally, the angiotensin converting enzyme ACE activity in the treated rats was significantly lower than the untreated rats. Extracts from the fruit and leaves seem to have diuretic effects, which may explain the traditional use of tribulus for kidney stones and other urinary problems such as painful urination.
For this reason, tribulus is also known as a water pill. Few individuals use tribulus for headache, gonorrhea, liver disease hepatitis , inflammation, coughs, chronic fatigue syndrome CFS , joint pain rheumatism , and dizziness vertigo. It is also used as a tonic and is believed to possess mood enhancing qualities. Research conducted on animal models has confirmed that tribulus also facilitates lower blood sugar levels and hence, could be used as a medication for diabetes mellitus.
Tribulus is a herb that may positively affect mood, stress, and anxiety. This can be helpful for women who juggle manifold responsibilities or tackle issues related to premenstrual syndrome PMS. Intake of tribulus terrestris supplements for a short time is probably harmless.
However, it is not recommended for pregnant and lactating women. Some common side effects are sleep disorders and irregular periods. Lab tests on animals link tribulus to problems in the development of the fetus. Tribulus supplements work well as preconception medication as they boost fertility in various ways.
However, one should refrain from Tribulus after conception as it has been identified with abortion agents. Also, men should be attentive to the possible connection between tribulus and prostate problems in the long run. Sometimes tribulus may interact with certain medications. It may intensify the effect of certain heart and blood pressure medicines, such as beta-blockers, digoxin , calcium channel blockers and diuretics.
For individuals who are undergoing diabetes treatment, tribulus might further lower blood sugar levels. It is advisable to check with a general physician before taking any herbal supplements. Tribulus may also proliferate the effect that steroids have on the body. Follow Medindia. By using our site, you acknowledge that you have read and understand our Cookie Policy , Privacy Policy , and our Terms of Use.
0コメント